Valproic Acid (Valparin)

The serum valproic acid test is a test to measure its concentration in the blood so as to maintain a therapeutic level. Valproic Acid, Free – Valproic acid, Sodium Valproate acid is used as a drug to treat certain types of seizures (epilepsy), prevent migraine headaches and bipolar disorder (cycle of depression and mania). It is at times prescribed in combination with other antiepileptic drugs such as phenytoin or phenobarb to control various kinds of seizures. Seizures affect the ability of the brain to transmit electrical impulses and regulate nerve activity. During a seizure, a patient may experience alterations in sight, taste and smell and may experience changes in consciousness. Head trauma, high fevers, severe infections and exposure to toxins, chronic conditions such as metabolic disorders and brain tumours may lead to convulsion. The frequency of seizures varies from a single incident to occasional seizures to repetitive. Bipolar disorder is a mental condition that is suggested by cycles of depression and mania. Doctors prescribe Valproate to help balance the moods of the person with bipolar disorder, especially mania. It is also given to some patients with frequent migraine headaches to help prevent their occurrence. Valproate levels must be kept within a thin therapeutic window. Too little may lead to the recurrence of symptoms, whereas too much may increase the side effects of the drug. This balance is not easily attained. Valproate dose must be administered carefully until a balanced concentration is reached in the blood. The actual amount that it takes to reach a balanced state varies from person to person. It is estimated that about 1% of our population, i.e., more than 10 million people are suffering from epilepsy in India. The lack of knowledge of anticonvulsants or anti-fits drugs, cultural beliefs, poverty, poor health support, shame, illiteracy and shortage of trained health workers leads to the gap in treatment. Infectious diseases play a vital role in seizures and long-term load, causing both outbreaks of new cases of epilepsy and existing cases.